Microzide

Microzide is a highly diuretic acting upon oral application. On chemical structure to the group of benzotiadiazina containing at position C (7) sulfonamide group. The presence of this group have in common with Microzide diakarbom. However, as the diuretic hydrochlorothiazide, significantly more efficient, and korboangidrazu inhibits to a much lesser extent than diakarb.

Diuretic effect Microzide, as well as other diuretics group benzotiadiazina, due to a decrease reabsorption of sodium and chlorine in the proximal (and partially in the distal) part of the convoluted tubules of kidneys, reabsorption of potassium and bicarbonate are also inhibited but to a lesser extent. Due to the strong increase in natriuresis while increasing excretion of chlorides Microzide Microzide is regarded as an active redstvo, sodium and chlorine are distinguished from the body in an equivalent amount. The drug has a diuretic effect as with acidosis and in alkalosis. Diuretic effect with prolonged use dihlotiazida not reduced.

With Diabetes insipidus, hydrochlorothiazide, as well as other diuretics benzotiadiazinovogo series, has "paradoxical" effect, causing a decrease in polyuria. There is also a decrease thirst. Greatly reduced the increased osmotic pressure of blood plasma that accompanies the disease. The mechanism of this effect is not clear enough. It is partly due to improved concentration ability of kidneys and inhibition of the activity center of thirst.

Microzide also has a hypotensive effect, which is usually observed at elevated blood pressure.

Microzide is used as a diuretic (salureticheskogo) means for stagnation in small and large circulation, associated with cardiovascular failure, cirrhosis of the liver with signs of portal hypertension, nephrosis and nephritis (except heavy progressive forms with a decrease in glomerular filtration rate); toxicosis pregnant ( nephropathy, edema, eclampsia): premenstrual state, accompanied by stagnant.

Microzide prevents delay in the body of sodium and water, accompanied by the use of mineralocorticoids, so he was appointed as edema caused by the hormones of the adrenal cortex and pituitary adrenocorticotropic hormone. Microzide prevents or reduces induced by these drugs increase blood pressure.

Microzide is rapidly absorbed. Diuretic effect after taking it develops quickly (within the first 1-2 h) and after a single dose lasts for up to 10-12 hours or more.

The drug is a valuable tool for the treatment of hypertension, especially accompanied by circulatory failure. Since hydrochlorothiazide usually potentiates the action of antihypertensive drugs, it is often prescribed in combination with these drugs, especially for patients with high blood pressure. Combined treatment can be effectively and with malignant course of hypertension. Dose of antihypertensive drugs on the combined use with hydrochlorothiazide may be reduced.

Hypotensive effect of hydrochlorothiazide is enhanced somewhat subject to salt-free diet, but severely restricts the reception of salt is not recommended.

In some cases, Microzide lowers intraocular pressure and normalizes ophthalmotonus glaucoma (mainly at subcompensated forms). Effect occurs in 24 - 48 hours after ingestion. Usually combined with hydrochlorothiazide instillation in the conjunctival sac eyes miotikov antiglaukomatoznyh or other means.

Assign Microzide into tablets (during or after a meal). Doses are selected individually depending on the severity of the disease and have no effect.

Single dose for patients when administered as a diuretic can vary from 0,025 g (25 mg) to 0.2 g (200 mg).

In mild cases, appoint 0,025-0,05 g (1-2 tablets) per day, in more severe cases - to 0.1 grams per day. Take a single dose (morning) or in two divided doses (morning). Sometimes prescribed to 0.2 grams per day. Increasing doses of more than 0,2 g impractical because further enhance diuresis usually occurs. The elderly with cerebral form of hypertension recommend taking smaller doses (0.0125 g 1-2 times a day).

The drug can be prescribed for 3-5-7 days in a row, and then make a break for 3-4 days and once again continue taking the drug, in milder cases, make a break after every 1 - 2 days. Long-term treatment is sometimes prescribed for 2-3 times a week. Course duration and total duration of treatment depend on the nature and severity of the disease, the resulting effect of portability. Treatment, especially in the early days, should be under medical supervision.

In hypertensive appoint 0,025-0,05 g (1-2 tablets) a day, usually with antihypertensive drugs.

Glaucoma patients assigned to 0,025 grams per day.

Microzide is usually well tolerated, but prolonged use may develop hypokalemia (usually mild) and gipohloremichesky alkalosis. Hypokalemia is more common in patients with liver cirrhosis and nephrosis. Gipohloremichesky alkalosis is more common in salt-free diet or a loss of chloride due to vomiting or diarrhea. Treatment Microzide recommended against the backdrop of a diet rich in potassium salts. When symptoms of hypokalemia should be appointed Panangin, potassium salt (potassium chloride solution at the rate of 2 g of drug per day). Sadi potassium are also encouraged to assign patients receiving both drugs Microzide with digitalis, and corticosteroids. When gipohloremicheskom alkalosis prescribe sodium chloride.

To prevent hypokalemia can take Microzide (as well as other saluretics) together with kaliysberegayuschimi diuretics.

When kidney disease combined with Microzide kaliysberegayuschimi and potassium-based drugs should not be.

When you receive Microzide (and other thiazide diuretics) can be observed decrease in excretion of uric acid from the body and the exacerbation of latent gout. In these cases, together with thiazide may be given allopurinol (see). Thiazides may also cause hyperglycemia and exacerbation of diabetes mellitus.

When large doses Microzide sometimes possible weakness, nausea, vomiting, diarrhea, and these events were decreased dose or a short break in taking the drug. In rare cases, there dermatitis.

When combined with ganglioblokiruyuschimi drugs should take into account the possibility of strengthening postural hypotension.

Contraindications: severe renal insufficiency, severe liver disease, severe diabetes and gout.

In the course of treatment Microzide to monitor the level of diuresis, electrolyte composition of blood in AD.

Should not be prescribed the drug in the first half of pregnancy.

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